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CAS No.: 61281-38-7

五味子甲素 Catalog No. CSN16433

Synonyms: Schizandrin-A;Wuweizisu-A;Deoxyschizandrin

Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 µM.

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实验方案

技术信息

生物活性

描述Schisandrin A (SchA) is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 µM^[3]. SchA produced concentration-dependent inhibition of MDZ (midazolam) metabolite formation in rat liver microsomes^[4]. Sch A reduced LPS-induced mammary injury and the production of pro-inflammatory mediators. Sch A also decreased the levels of pro-inflammatory mediators and activated Nrf2 signaling pathway in mouse mammary epithelial cells (mMECs)^[5]. Schisandrin A could suppress the IL-1β-induced production of NO and PGE2 in rat chondrocytes. In vivo, Schisandrin A prevented cartilage damage in rat OA (Osteoarthritis) model^[6]. Sch A significantly ameliorated behavioural abnormalities and increased the number of nigral dopaminergic neurons detected by tyrosine hydroxylase immunohistochemistry. Pre-treatment with Sch A significantly decreased the levels of the inflammatory mediators IL-6, IL-1β, and TNF-α and markedly improved antioxidant defences by inhibiting the activity of MDA and increasing that of SOD. Furthermore, Sch A activated expression of the autophagy-related proteins LC3-II, beclin1, parkin, and PINK1 and increased mTOR expression^[7]. Sch A appeared to protect against DON(deoxynivalenol)-induced cytotoxicity in HT-29 cells, and significantly lessened the DON-stimulated intracellular ROS and NO species production^[8]. Schisandrin A has a protective effect against LPS-induced inflammatory and oxidative responses in RAW 264.7 cells by inhibiting the NF-κB, MAPK and PI3K/Akt pathways^[9].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4009 mL
- 12.0046 mL
- 24.0092 mL
- 5 mM
- 0.4802 mL
- 2.4009 mL
- 4.8018 mL
- 10 mM
- 0.2401 mL
- 1.2005 mL
- 2.4009 mL

技术信息

CAS号

61281-38-7

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H32O6

运输

蓝冰

分子量

416.51

别名

Schizandrin-A;Wuweizisu-A;Deoxyschizandrin;Deoxyschisandrin;五味子甲素

溶解度

DMSO	120.0 mg/mL (288.1 mM)
Water	insoluble

动物实验配方

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